I've been using the Estradiol gel for about a week now. I'm supposed to apply it twice a day, but when I first used it, it caused a bit of irritation so I decided to go once a day for a few days to get used to it in a more gradual way and try to prevent an amount of irritation that would make me stop using it. So on Tuesday and Wednesday I felt no itchy/burniness so I decided to start using it twice a day.
Then last night I went to a baseball game. I sat on a hard plastic seat for 4 hours. By itself, that would have caused enough discomfort, but in combination with the Estradiol, man, I am super itchy today! I hope it won't last because I have to use this stuff for 6 months and I really don't want to have an itchy vagina for that long.